Why the study?
Does the site of blood sampling (arterial vs venous) and surgical stress affect the calculated whole body clearance of norepinephrine?
Population
7 patients evaluated pre- and postoperatively
Comparison
Intravenous infusion of L[H]norepinephrine for… vs Arterial vs venous sampling; preoperative vs…
Design
Other
Follow-up
pre- and postoperatively
Authors
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Venous sampling may overestimate norepinephrine clearance; leaves open optimal methods while extending kinetic data on surgical stress responses.
Does the site of blood sampling (arterial vs venous) and surgical stress affect the calculated whole body clearance of norepinephrine?
Calculation of plasma norepinephrine clearance based on venous sampling overestimates clearance due to peripheral uptake, and surgical stress increases plasma NE via increased appearance rate rather than decreased clearance.
Hilsted et al. (1983) studied this question.
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