Complex genetic contribution of the Apo AI-CIII-AIV gene cluster to familial combined hyperlipidemia. Identification of different susceptibility haplotypes.
Population
18 familial combined hyperlipidemia pedigrees, including 18 probands, 178 hyperlipidemic relatives, 210…
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Supports apo AI-CIII-AIV epistasis in hyperlipidemia; leaves open prospective validation before clinical use.
Structured PICO
P
Population
18 familial combined hyperlipidemia (FCH) pedigrees, including 18 probands, 178 hyperlipidemic relatives, 210 normolipidemic relatives, and 176 spouses (total n=582)
O
Outcome
Association of apo AI-CIII-AIV gene cluster haplotypes with plasma lipids (cholesterol, triglycerides, apo CIII) and FCH phenotypesurrogate
The apo AI-CIII-AIV gene cluster contributes to the familial combined hyperlipidemia phenotype through complex epistatic interactions between different haplotypes.
Cite This Study
Dallinga‐Thie et al. (1997) studied this question.