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October 1, 1977The Journal of Cell BiologyOpen Access

Calcium content and distribution as a function of growth and transformation in the mouse 3T3 cell

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Population

Mouse 3T3 cells (normal and SV40-transformed)

Comparison

Growth stage progression, SV40 virus… vs Normal 3T3 cells during exponential growth or in…

Design

Preclinical

Authors

JTJ T TupperSyracuse UniversityFZFlavia ZorgniottiSyracuse University

Discussion

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Implication

Surface Ca correlates with growth inhibition in fibroblasts; leaves open relevance to cardiovascular cells or in vivo settings.

Structured PICO

P
Population
Mouse 3T3 cells (normal and SV40-transformed)
I
Intervention
Growth stage progression, SV40 virus transformation, and alteration of media serum levels (10%, 4%, 0.5%)
C
Comparator
Normal 3T3 cells during exponential growth or in standard serum media
O
Outcome
Total cellular calcium content and EGTA-removable calcium fractionsurrogate

An increase in calcium associated with the cell surface correlates with growth inhibition in mouse 3T3 cells.

Cite This Study

Tupper et al. (1977) studied this question.

synapsesocial.com/papers/6a717134fe4101aa97e09364https://doi.org/10.1083/jcb.75.1.12
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of serum on the growth of balb 3T3 A31 mouse fibroblasts and an SV40‐transformed derivative1976 · 90 citations
  2. 2Different calcium requirements for proliferation of conditionally and unconditionally tumorigenic mouse cells.1976 · 138 citations
  3. 3Kinetic Analyses of Calcium Movements in HeLa Cell Cultures1969 · 101 citations
  4. 4Roles of Calcium, Serum, Plasma, and Folic Acid in the Control of Proliferation of Normal and Rous Sarcoma Virus-Infected Chicken Fibroblasts1973 · 191 citations
  5. 5Mutual potentiation by magnesium and calcium of growth in animal cells.1976 · 67 citations