Beta-Fibrinogen G–455A Polymorphisms and Recurrent Miscarriage

BACKGROUND/AIMS: The aim of this study was to investigate whether differences could be detected in genotype and allele frequencies of β-fibrinogen G-455A in relation to recurrent miscarriage (RM). METHODS: β-Fibrinogen G-455A polymorphism was investigated by sequencing analysis in 98 women with RM and 78 control women who had no history of miscarriage (controls). RESULTS: The frequency of the -455 A/A genotype of β-fibrinogen was significantly different in women with RM compared with control women. The A/A genotype was found in 8 women of Group 1 (8.2%), but was not detected in any woman of the control group. In contrast, no differences were found in the allele frequencies between RM and control women. CONCLUSIONS: Women with the A/A genotype could have an increased risk of RM. However, the allele frequencies were similar between women with recurrent pregnancy loss and control women, suggesting that the effect of β-fibrinogen polymorphisms on RM, if any, is actually very slight.