Progress in erectile dysfunction therapy through drug delivery system

A man’s aptitude to acquire and continue an erection is frequently equated with masculinity and virility and can greatly influence men’s confidence. The sexual healthiness is a significant determinant of the worth of life. Erectile dysfunction (ED) as the inability to have or sustain a penile erection long enough to have momentous sexual intercourse with a partner. As per the literature, it is revealed that the millions of men populations are suffering from ED and there is an extreme need to overcome the ED. The various natural traditional herbs, synthetic pioneered chemical entities/potentials are preferred to treat ED. The present review discusses ED therapy including drug selection, application site, and choice of formulation. Moreover, this review updates the various pharmaceutical formulation such as liposomes, ethosomes, transfersomes, nanoemulsion, self-nano-emulsifying drug delivery system, solid dispersion, penetrosomes, solid lipid nanoparticles, and nanostructured lipid carriers development in ED therapy through the oral route, topical and nasal route, etc., which are helpful for researchers to develop new nanocarriers based formulations.