Serum precipitins against rubella virus antigens theta and iota have distinct temporal profiles and may reliably reflect the state of immunity.
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Distinct anti-theta and anti-iota kinetics may aid rubella immunity assessment; leaves open their clinical utility pending prospective validation.
Two specific precipitating antigens, theta and iota, have been detected by immunodiffusion of rubella virus reactants. They are subviral in size, and neither appears to be an active virus hemagglutinin. In patients with rubella, anti-θ precipitin rises promptly, along with antihemagglutinin, and can be detected for years, whereas anti-θ is made more slowly and declines sooner. The serum precipitins may reliably reflect the state of immunity.
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George L. Le Bouvier (1969) studied this question.
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