Why the study?
SGK1 is associated with heart disease through its involvement in cardiac hypertrophy and fibrosis, but the signaling pathways associated with its activity in various heart conditions required review.
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Design
Review
SGK1 modulation may hold therapeutic promise in cardiac disease; leaves open need for clinical validation.
Cardiac diseases encompass a wide range of conditions that affect the structure and function of the heart. These conditions are a leading cause of morbidity and mortality worldwide. The serum- and glucocorticoid-inducible kinase 1 (SGK1) is a serine/threonine kinase that plays a significant role in various cellular processes, including cell survival and stress response. Alterations in SGK1 activity can have significant impacts on health and disease. Multiple research findings have indicated that SGK1 is associated with heart disease due to its involvement in cardiac hypertrophy and fibrosis. This article reviews different signaling pathways associated with SGK1 activity in various heart conditions, including the SGK1/NF-κB and PI3K/SGK1 pathways.
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Yarmohammadi et al. (2024) studied this question.
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