Why the study?
Does SGK1 activation regulate cardiomyocyte survival and hypertrophic response during acute biomechanical stress?
Does SGK1 activation regulate cardiomyocyte survival and hypertrophic response during acute biomechanical stress?
SGK1 is dynamically regulated during acute biomechanical stress in the heart, inhibiting cardiomyocyte apoptosis while enhancing the hypertrophic response.
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SGK1 may modulate cardiomyocyte survival and hypertrophy under stress; hypothesis-generating and leaves open human therapeutic relevance.
Aoyama et al. (2005) studied this question.
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