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September 14, 2007Journal of Biological ChemistryOpen Access

Glycogen Synthase Kinase-3α Reduces Cardiac Growth and Pressure Overload-induced Cardiac Hypertrophy by Inhibition of Extracellular Signal-regulated Kinases

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Population

Cardiac-specific GSK-3alpha transgenic mice (Tg) and cultured cardiac myocytes

Comparison

Transgenic overexpression of GSK-3alpha… vs Non-transgenic mice; control cultured myocytes

Design

Preclinical

Follow-up

4 weeks (for TAC)

Authors

PZPeiyong ZhaiSGShumin GaoEHEric Holle

Discussion

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Overview

These results should not change practice; leaves open isoform-selective GSK-3α targeting in human pressure-overload HF.

Structured PICO

P
Population
Cardiac-specific GSK-3alpha transgenic mice (Tg) and cultured cardiac myocytes
I
Intervention
Transgenic overexpression of GSK-3alpha; Adenovirus-mediated overexpression of GSK-3alpha; Knockdown of GSK-3alpha
C
Comparator
Non-transgenic (NTg) mice; control cultured myocytes
O
Outcome
Cardiac growth (left ventricular weight and cardiac myocyte size) and pressure overload-induced cardiac hypertrophy after transverse aortic constriction (TAC)surrogate

GSK-3alpha inhibits cardiac growth and pressure overload-induced hypertrophy but promotes fibrosis and apoptosis via ERK inhibition.

Cite This Study

Zhai et al. (2007) studied this question.

synapsesocial.com/papers/6a7c1bd2f056b38aaddf8a89https://doi.org/10.1074/jbc.m705133200
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Glycogen Synthase Kinase 3β Regulates GATA4 in Cardiac Myocytes2001 · 231 citations
  2. 2Extracellular Signal-regulated Kinase Plays an Essential Role in Hypertrophic Agonists, Endothelin-1 and Phenylephrine-induced Cardiomyocyte Hypertrophy2000 · 198 citations
  3. 3Increased Collagen Deposition and Diastolic Dysfunction but Preserved Myocardial Hypertrophy After Pressure Overload in Mice Lacking PKCε2005 · 87 citations
  4. 4Ras/Erk Signaling Is Essential for Activation of Protein Synthesis by Gq Protein-Coupled Receptor Agonists in Adult Cardiomyocytes2002 · 142 citations
  5. 5Glycogen synthase kinase-3β mediates convergence of protection signaling to inhibit the mitochondrial permeability transition pore2004 · 1,001 citations