Why the study?
What is the relative impact of type 1 diabetes mellitus and hypertension on aortic elasticity?
What is the relative impact of type 1 diabetes mellitus and hypertension on aortic elasticity?
Hypertension is the primary driver of reduced aortic elasticity in patients with type 1 diabetes mellitus, whereas the diabetes itself has only a slight effect.
Hypertension primarily impairs aortic elasticity in DM1; leaves open whether DSCT measures warrant routine clinical use or outcome trials.
OBJECTIVE: To investigate the characteristics of aortic elasticity in type 1 diabetes mellitus (DM1) patients with hypertension using dual-source computed tomography (DSCT). METHODS: Subjects were divided into four groups: 31 with hypertension (EH group), 28 with DM1 (DM1 group), 30 with hypertension and DM1 (DM1 + EH group), and 30 healthy volunteers (control group, CG). ECG-gated DSCT was used to measure the cross-sectional area of the aorta in diastole and systole and calculate the aortic elasticity (D). Analysis of variance and multiple linear regression were used for statistical analysis. RESULTS: Compared with the CG, aortic elasticity (D) in the DM1 group patients was not significantly decreased. Compared with the EH group, the DM1 + EH group showed no significant change. The aortic elasticity (D) in the EH and DM1 + EH groups was significantly lower than that in the CG and DM1 group. CONCLUSION: DM1 slightly affects the aortic elasticity of the descending aorta, whereas hypertension exerts the main effect.
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Wang et al. (2018) studied this question.
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