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Demonstrates that balancing the stoichiometry of Gata4, Mef2c, and Tbx5 affects direct cardiac reprogramming efficiency, suggesting an avenue to improve induced cardiomyocyte yields.
Generation of induced cardiac myocytes (iCMs) directly from fibroblasts offers great opportunities for cardiac disease modeling and cardiac regeneration. A major challenge of iCM generation is the low conversion rate of fibroblasts to fully reprogrammed iCMs, which could in part be attributed to unbalanced expression of reprogramming factors Gata4 (G), Mef2c (M), and Tbx5 (T) using the current gene delivery approach.
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Qian et al. (2020) studied this question.
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