Population
In vitro models/apoptotic extracts and purified caspases acting on gene products associated with triplet…
Design
Preclinical
Authors
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Caspase cleavage may represent a shared step in polyglutamine disorders; hypothesis-generating and requires human validation before any therapeutic consideration.
Caspase cleavage of polyglutamine-containing proteins may represent a common pathogenic step in several neurodegenerative triplet expansion disorders.
Wellington et al. (1998) studied this question.
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