What question did this study set out to answer?

To determine whether pancreatic islet mass expansion in obese (ob/ob) mice occurs via the formation of new islets (neogenesis) or the enlargement of existing islets.

July 1, 2003DiabetesOpen Access

Increased Islet Volume but Unchanged Islet Number in ob/ob Mice

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Authors

TBTroels BockHolbæk Sygehus BPBente PakkenbergBispebjerg Hospital KBKarsten BuschardUniversity of Copenhagen

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Implication

Comparative animal study reveals islet mass expansion occurs via enlargement of existing islets in ob/ob mice, indicating that spontaneous islet neogenesis does not occur.

Key Points

To determine whether pancreatic islet mass expansion in obese (ob/ob) mice occurs via the formation of new islets (neogenesis) or the enlargement of existing islets.
Quantified total islet number and mean islet volume in the intact pancreas of ob/ob mice (N=8) compared to lean ob/+ control mice (N=8) using a stereological quantification method.
Total islet volume increased by a factor of 3.6 in ob/ob mice compared with ob/+ control mice.
Total islet count did not differ significantly between groups (3,193 ± 160 islets in ob/ob vs. 3,184 ± 142 islets in ob/+ mice, P = 0.97).
The coefficient of variation in islet volume distribution was identical between groups, demonstrating proportional enlargement of existing islets without net new islet formation.

Cite This Study

Bock et al. (2003) studied this question.

synapsesocial.com/papers/6a717b77e5469ee92be1ff0e https://doi.org/10.2337/diabetes.52.7.1716

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Implication

Comparative animal study reveals islet mass expansion occurs via enlargement of existing islets in ob/ob mice, indicating that spontaneous islet neogenesis does not occur.

Increased Islet Volume but Unchanged Islet Number in ob/ob Mice

Discussion

Member takes

Implication

Key Points

Cite This Study

Increased Islet Volume but Unchanged Islet Number in ob/ob Mice

Discussion

Member takes

Implication

Key Points

Cite This Study

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