Why the study?
Does preoperative administration of aspirin reduce the incidence of acute kidney injury and mortality in patients undergoing cardiac surgery?
Does preoperative administration of aspirin reduce the incidence of acute kidney injury and mortality in patients undergoing cardiac surgery?
Preoperative aspirin administration may protect renal function and improve survival outcomes in patients undergoing cardiac surgery, potentially by maintaining renal blood perfusion and reducing inflammation.
Preoperative aspirin may reduce AKI and mortality after cardiac surgery; leaves open confirmation in randomized trials.
Background Acute kidney injury (AKI) was one of the serious complication after cardiac surgery with reported incidence of more than 30％,which resulted in increased mortality.Aspirin was regularly used for therapy and prophylaxis in patients with cardiovascular diseases.Objective This review aims to present a general report of recent studies about the benefits of aspirin on renal function after cardiac surgery and analyse its possible mechanisms.Content Recent retrospective clinical investigations and randomised controlled trails indicated that aspirin significantly decreased the incidence of AKI (acute renal injury/dysfunction),in-hospital mortality,accepted dialysis and improved outcomes after cardiac surgery.Trend The protective mechanisms for renal after cardiac surgery by preoperative administration of aspirin still need further investigation.The main mechanisms may be relate to maintain renal blood perfusion and reduce inflammatory reaction.
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He et al. (2013) studied this question.
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