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Picroliv, an iridoid glycoside mixture from the root and rhizome of Picrorhiza kurrooa , showed dose‐dependent protective activity on isolated hepatocytes ( ex vivo ) against thioacetamide‐induced hepatic damage in the rat. It enhanced the percentage of viable hepatic cells. Picroliv also antagonized the changes in the enzymes GOT, GPT and alkaline phosphatase produced by thioacetamide both in the isolated hepatocyte suspension as well as in serum. It was found to be more potent than silymarin, a known hepatoprotective agent.
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Visen et al. (1991) studied this question.
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