Effects of phytate on mineral bioavailability. in vitro studies on Mg²⁺, Ca²⁺, Fe³⁺, Cu²⁺ and Zn²⁺ (also Cd²⁺) solubilities in the presence of phytate

The effect of phytate on the solubility of some minerals (Mg 2+ , Ca 2+ , Fe 3+ , Cu 2+ and Zn 2+ ) has been investigated in vitro at 37°C, under pH conditions which may be encountered in the duodenum. The observed solubility trends as a function of phytate concentration and pH result from the formation of complexes having different stoichiometries and solubilities as the conditions are varied. Possible structures for these complexes are proposed. In view of the ever‐increasing concern over cadmium toxicity and a recent report which indicates that intestinal absorption of Cd 2+ is affected by phytate, this ion was included as part of this study.