Experimental study reveals loss of hematopoietic stem cells in adult bone marrow after Tel/Etv6 deletion, indicating an essential survival role.
Key Points
To investigate the role of the transcription factor Tel/Etv6 in the maintenance and survival of adult hematopoietic stem cells.
Inactivated the Tel/Etv6 gene in adult bone marrow hematopoietic stem cells and examined the survival of stem cells alongside downstream blood cell lineages.
Assessed post-lineage commitment developmental consequences following the targeted deletion of Tel/Etv6.
Targeted inactivation of Tel/Etv6 resulted in the rapid loss of adult hematopoietic stem cells in bone marrow, whereas downstream committed progeny temporarily sustained blood formation.
Loss of Tel/Etv6 after lineage commitment selectively impaired the maturation of megakaryocytes without broad defects in other differentiated lineages.