Peroxisome Proliferator-Activated Receptor β/δ (PPARβ/δ) but Not PPARα Serves as a Plasma Free Fatty Acid Sensor in Liver

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Population

Transgenic and knockout mice for Angptl4, and wild-type mice models

Comparison

Fasting, Wy14643, and genetic manipulation vs Control conditions (fed state, wild-type)

Design

Preclinical

Authors

Discussion

Suggests PPARbeta/delta as hepatic FFA sensor in fasting; hypothesis-generating for metabolic therapies, pending human studies.

Population

Transgenic and knockout mice for Angptl4, and wild-type mice models

Intervention

Fasting, Wy14643 (PPARalpha agonist), and genetic manipulation (Angptl4 transgenic/knockout)

Comparator

Control conditions (fed state, wild-type)

Outcome

Gene expression regulation (Lpin2, St3gal5, Aldh3a2, Cpt2) and transcription factor bindingsurrogate

PPARbeta/delta, but not PPARalpha, acts as a plasma free fatty acid sensor in the liver, regulating genes like Lpin2 and St3gal5 during fasting.

Sanderson et al. (2009) studied this question.

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