February 15, 2006AJP Endocrinology and Metabolism

Localized accumulation of angiotensin II and production of angiotensin-(1–7) in rat luteal cells and effects on steroidogenesis

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Population

Rat luteal cells

Comparison

Angiotensin-converting enzyme inhibitor, prolyl… vs Control or alternative inhibitors

Design

Preclinical

Authors

JPJohn R. PepperellWomen & Infants Hospital of Rhode Island GNGábor NémethUniversity of Szeged YYYuji YamadaSuita Municipal Hospital

Discussion

Member takes

Implication

Hypothesis-generating for intracellular AT1 modulation of luteal steroidogenesis; leaves open relevance to human physiology or practice.

Structured PICO

Population

Rat luteal cells

Intervention

Angiotensin-converting enzyme inhibitor (quinapril), prolyl endopeptidase inhibitor (Z-proprolinal), sulfhydryl protease inhibitor (PCMS), serine protease inhibitor (PMSF), AT1 receptor antagonist (losartan), and AT2 receptor antagonist (PD-123319)

Comparator

Control or alternative inhibitors

Outcome

Subcellular distribution of angiotensin II, accumulation of angiotensin peptides, and luteinizing hormone (LH)-dependent progesterone productionsurrogate

Angiotensin peptides may modulate steroidogenesis in rat luteal cells, acting in part through intracellular AT1 receptors.

Cite This Study

Pepperell et al. (2006) studied this question.

synapsesocial.com/papers/6a718a838031ec7bb1dd02fc https://doi.org/10.1152/ajpendo.00205.2005

View Full Paper

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Localized accumulation of angiotensin II and production of angiotensin-(1–7) in rat luteal cells and effects on steroidogenesis

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Localized accumulation of angiotensin II and production of angiotensin-(1–7) in rat luteal cells and effects on steroidogenesis

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider