January 1, 1997International Review of Psychiatry
On the nature and mechanisms of obstetric influences in schizophrenia: a review and synthesis of epidemiologic studies
Why the study?
Do obstetric complications, particularly perinatal hypoxia, interact with genetic predisposition to increase the risk of schizophrenia?
Population
Individuals with schizophrenia, unaffected siblings, offspring of schizophrenics, high-risk samples, and…
Comparison
Obstetric complications, particularly labor and… vs Unaffected individuals from the general population
Design
Review
Authors
Discussion
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Implication
Supports gene-environment interactions in schizophrenia risk; hypothesis-generating and should not yet change clinical practice.
Structured PICO
Do obstetric complications, particularly perinatal hypoxia, interact with genetic predisposition to increase the risk of schizophrenia?
P
Population
Individuals with schizophrenia, unaffected siblings, offspring of schizophrenics, high-risk samples, and representative birth cohorts
I
Intervention
Obstetric complications, particularly labor and delivery complications (LDCs) and perinatal hypoxia
C
Comparator
Unaffected individuals from the general population
O
Outcome
Development of schizophrenia
Labor and delivery complications, particularly perinatal hypoxia, interact with genetic predisposition to increase the risk of schizophrenia, suggesting that predisposing genes may confer heightened susceptibility to hypoxic-ischemic neuronal injury.
Cite This Study
Tyrone D. Cannon (1997) studied this question.