What question did this study set out to answer?

The aim is to determine if P-wave signal averaging can identify individuals at risk for atrial fibrillation by observing conduction areas.

November 1, 2002Clinical CardiologyOpen Access

Signal‐Averaged P‐Wave Analysis of Normal Controls and Patients with Paroxysmal Atrial Fibrillation: A Study in Gender Differences, Age Dependence, and Reproducibility

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Why the study?

Does P-wave signal averaging differentiate patients with paroxysmal atrial fibrillation from normal controls?

Population

280 individuals, comprising 199 normal controls and 81 patients with paroxysmal atrial fibrillation

Comparison

P-wave signal averaging from the surface… vs Normal controls

Design

Case-control

Authors

ADAnwer DhalaAurora Sinai Medical Center DUDonald A. UnderwoodCleveland Clinic RLRobert B. LemanMedical University of South Carolina

Discussion

Member takes

Implication

May support P-wave signal averaging for paroxysmal AF detection; leaves open prospective validation before clinical adoption.

Key Points

The aim is to determine if P-wave signal averaging can identify individuals at risk for atrial fibrillation by observing conduction areas.
P-wave signal averaging from electrocardiograms of 199 normal controls and 81 patients with paroxysmal atrial fibrillation was conducted.
An automated, P-triggered high-resolution signal analysis was utilized.
Reproducibility of metrics was assessed through consecutive measurements of filtered P-wave duration.
Filtered P-wave duration significantly differed between controls (120 ms) and patients (145 ms), as did the P-wave integral (666 vs. 868).
Filtered P-wave duration showed excellent reproducibility with r=0.96 and r2=0.92 across tests.
Sensitivity for predicting atrial fibrillation risk was 80% in men and 81% in women, with specificity at 92% and 90%, respectively.

Structured PICO

Does P-wave signal averaging differentiate patients with paroxysmal atrial fibrillation from normal controls?

Population

280 individuals, comprising 199 normal controls and 81 patients with paroxysmal atrial fibrillation

Intervention

P-wave signal averaging from the surface electrocardiogram using an automated, P-triggered, high-resolution signal

Comparator

Normal controls

Outcome

Filtered P-wave duration and P-wave integralsurrogate

P-wave signal averaging is a reproducible, non-invasive electrocardiographic tool that can identify patients with paroxysmal atrial fibrillation with high sensitivity and specificity.

Cite This Study

Dhala et al. (2002) studied this question.

synapsesocial.com/papers/6a718b1af44fa9f079df532c https://doi.org/10.1002/clc.4960251109

Topics

Atrial fibrillation Persistent AF management

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Signal‐Averaged P‐Wave Analysis of Normal Controls and Patients with Paroxysmal Atrial Fibrillation: A Study in Gender Differences, Age Dependence, and Reproducibility

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Signal‐Averaged P‐Wave Analysis of Normal Controls and Patients with Paroxysmal Atrial Fibrillation: A Study in Gender Differences, Age Dependence, and Reproducibility

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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