Why the study?
Bipolar disorder is an inflammatory and metabolic disease, and both the disorder and its treatments may affect cardiovascular disease risk.
Is arterial stiffness increased in patients with bipolar disorder type I compared to healthy controls?
Is arterial stiffness increased in patients with bipolar disorder type I compared to healthy controls?
Arterial stiffness and intima-media thickness may be relevant markers for investigating cardiovascular disease risk in patients with bipolar disorder.
Increased arterial stiffness in BD may flag higher CVD risk; leaves open whether assessment improves outcomes or requires prospective trials.
Objective: Bipolar disorder (BD) is an inflammatory and metabolic disease. The disease and the drugs used to treat it may affect cardiovascular disease (CVD) risk. The aim of this study is to investigate arterial stiffness in patients with BD and compare them with healthy controls. Methods: Thirty-nine patients with BD type I in remission and 39 healthy control subjects were included in the study. Carotid and femoral artery intima-media thickness (IMT) and arterial thickness parameters were measured by Doppler ultrasonography. Results: = -0.391, respectively). No predictor was observed between drug dose and arterial stiffness parameters. Conclusion: Arterial stiffness might be investigated for its potential to reduce CVD risk in patients with BD. Given the established CVD complications in this patient population, further studies are needed to determine whether the results are specific to antipsychotic treatment or BD and to clarify the potential arterial protective effects of mood stabilizers.
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Kılıçaslan et al. (2023) studied this question.
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