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Since its introduction in 1921 the efficacy of bacille Calmette-Guerin (BCG) has been extensively debated, yet it remains one of the most widely used of all vaccines today. BCG is compulsory in 64 countries and is officially recommended in a further 118.' Schedules differ widely, a testimony to the lack of consensus regarding timing of immunisation. There is growing evidence that neonatal BCG immunisation significantly reduces the risk of clinical tuberculosis.
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Clarke et al. (1992) studied this question.
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