Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
May 31, 2010The Journal of General PhysiologyOpen Access

Multi-scale electrophysiology modeling: from atom to organ

View Full Paper
Ask AI
Bookmark
Share

Population

Computational model of the slow delayed rectifier K+ channel (IKs) and cardiac electrophysiology

Design

Review

Authors

JSJonathan R. SilvaElectrophysiologyYoram RudyYoram RudyElectrophysiology

Discussion

Loading...

Member takes

Implication

No immediate clinical application; leaves open experimental validation of multi-scale IKs predictions in arrhythmia models.

Structured PICO

P
Population
Computational model of the slow delayed rectifier K+ channel (IKs) and cardiac electrophysiology

Multi-scale computational modeling of ion channels provides a framework to understand their role in cardiac electrophysiology from the atomic to the organ level.

Cite This Study

Silva et al. (2010) studied this question.

synapsesocial.com/papers/6a718b7a5d37378ac1deab67https://doi.org/10.1085/jgp.200910358
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes.1994 · 1,599 citations
  2. 2A multiscale model linking ion-channel molecular dynamics and electrostatics to the cardiac action potential2009 · 135 citations
  3. 3Structural Models for the KCNQ1 Voltage-Gated Potassium Channel2007 · 104 citations
  4. 4Location of KCNE1 relative to KCNQ1 in the I KS potassium channel by disulfide cross-linking of substituted cysteines2009 · 86 citations
  5. 5Subunit Interaction Determines I Ks Participation in Cardiac Repolarization and Repolarization Reserve2005 · 215 citations