Why the study?
Does the rare APOC3(rs138326449) variant affect metabolic measures independently of LPL in European population cohorts?
Does the rare APOC3(rs138326449) variant affect metabolic measures independently of LPL in European population cohorts?
The rare APOC3(rs138326449) loss-of-function mutation is associated with 81 metabolic measures, demonstrating LPL-independent effects on VLDL composition.
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Highlights LPL-independent metabolic effects of APOC3 variant; leaves open clinical relevance for CHD risk reduction.
Drenos et al. (2016) studied this question.
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