December 1, 2002PEDIATRICS

Intussusception, Rotavirus, and Oral Vaccines: Summary of a Workshop

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Why the study?

Does the rhesus-human reassortant rotavirus tetravalent vaccine cause intussusception in vaccine recipients?

Population

Populations administered the rhesus-human reassortant rotavirus tetravalent vaccine (Rotashield)

Design

Review

Authors

GPGeorges PeterKenya Medical Research Institute MMMartin G. MyersMarquette University

Discussion

Member takes

Implication

Informs rotavirus vaccine policy; leaves open whether current formulations carry similar risk.

Structured PICO

Does the rhesus-human reassortant rotavirus tetravalent vaccine cause intussusception in vaccine recipients?

Population

Populations administered the rhesus-human reassortant rotavirus tetravalent vaccine (Rotashield)

Intervention

Rhesus-human reassortant rotavirus tetravalent vaccine (Rotashield)

Outcome

Intussusceptionsafety

This workshop summary highlights the causal relationship between the Rotashield vaccine and intussusception, emphasizing the need for safe rotavirus vaccines globally.

Limitations

Pathogenesis of the association remains unknown
Unclear if the association exists with other candidate rotavirus vaccine strains
Unclear if attributable risk would be similar in other populations

Cite This Study

Peter et al. (2002) studied this question.

synapsesocial.com/papers/6a718c3b26a7f98052ddda71 https://doi.org/10.1542/peds.110.6.e67

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Bookmark

Intussusception, Rotavirus, and Oral Vaccines: Summary of a Workshop

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Intussusception, Rotavirus, and Oral Vaccines: Summary of a Workshop

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider