Why the study?
Does immunization with cardiac myosin peptides induce inflammatory heart disease in humanized mice expressing human CD4 and HLA-DQ6?
Population
Double CD4- and CD8-deficient C57BL/6 mice transgenic for human CD4 (hCD4) and human HLA-DQ6
Comparison
Immunization with cardiac myosin or… vs hCD4 single transgenic littermates
Design
Preclinical
Authors
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Establishes humanized mouse model of autoimmune myocarditis; leaves open whether HLA-DQ6 drives human inflammatory cardiomyopathy.
Does immunization with cardiac myosin peptides induce inflammatory heart disease in humanized mice expressing human CD4 and HLA-DQ6?
The generation of humanized mice susceptible to peptide-induced inflammatory heart disease provides experimental evidence that human inflammatory cardiomyopathy can be caused by organ-specific autoimmunity.
Bachmaier et al. (1999) studied this question.
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