The hepatic uptake of high density lipoprotein cholesteryl ester was determine in a nonrecycling isolated rat liver perfusion. High density lipoprotein rich in the E apoprotein (apoE) showed about 10 times more uptake of the ester on a single pass than the bulk of the high density lipoproteins rich in the A-I protein. The apoportein recoveries in the liver paralleled the ester for both lipoproteins. The uptake appeared to occur primarily in the hepatic parenchymal cell. Addition of human C-III-1 apoprotein to the rat apoE-rich high density lipoprotein inhibited the hepatic uptake of its constituents.
No takes yet. Share an insight, caveat, or question.
Quarfordt et al. (1980) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: