What question did this study set out to answer?

To evaluate whether intrauterine undernutrition causes endothelial dysfunction and alters nitric oxide synthase expression and activity in adult offspring, assessing potential sex-specific differences.

October 1, 2002Cardiovascular ResearchOpen Access

Intrauterine undernutrition: expression and activity of the endothelial nitric oxide synthase in male and female adult offspring

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Authors

MFMaria do Carmo FrancoUniversity of Maryland, Baltimore

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Implication

Animal study demonstrates that maternal undernutrition impairs endothelial nitric oxide synthase and causes hypertension in adult offspring, indicating sex-specific vascular pathways.

Key Points

To evaluate whether intrauterine undernutrition causes endothelial dysfunction and alters nitric oxide synthase expression and activity in adult offspring, assessing potential sex-specific differences.
Pregnant female Wistar rats were fed either a normal diet or a 50% intake restricted diet throughout gestation.
At 14 weeks of age, male and female offspring were assessed for vascular reactivity, eNOS and iNOS gene expression, eNOS activity, and circulating estrogen levels in females.
Intrauterine undernutrition induced adult hypertension in both sexes, with more severe elevation observed in male offspring.
Aortic rings from nutritionally restricted offspring displayed heightened contractile responses to norepinephrine and diminished vasodilation to acetylcholine, with preserved responses to sodium nitroprusside.
Maternal undernutrition reduced aortic eNOS gene expression exclusively in males, decreased eNOS activity in both sexes, and impaired estrogen synthesis in females.

Cite This Study

Maria do Carmo Franco (2002) studied this question.

synapsesocial.com/papers/6a718d37f44fa9f079df555c https://doi.org/10.1016/s0008-6363(02)00508-4

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Implication

Animal study demonstrates that maternal undernutrition impairs endothelial nitric oxide synthase and causes hypertension in adult offspring, indicating sex-specific vascular pathways.

Intrauterine undernutrition: expression and activity of the endothelial nitric oxide synthase in male and female adult offspring

Discussion

Member takes

Implication

Key Points

Cite This Study

Intrauterine undernutrition: expression and activity of the endothelial nitric oxide synthase in male and female adult offspring

Discussion

Member takes

Implication

Key Points

Cite This Study

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