We report a simple approach to conjugate monodisperse Fe3O4 nanoparticles with mPEG molecules via a readily available linker, trichloro-s-triazine (TsT). The mPEG-dopamine coated nanoparticles are stable in buffer at various pH values greater than 7. This approach can be extended to the coupling of various hydrophilic macromolecules to iron oxide nanoparticles.
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Xie et al. (2006) studied this question.
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