Effects of dabigatran according to age in atrial fibrillation
Why the study?
Does dabigatran compared with warfarin have age-dependent effects on stroke and bleeding in patients with atrial fibrillation?
Population
18,113 patients with atrial fibrillation from the RE-LY trial, stratified by age categories
Comparison
Dabigatran 150 mg twice daily or 110 mg twice… vs Warfarin
Design
RCT
Authors
Discussion
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Member takes
Implication
Dabigatran benefits consistent across ages in AF; leaves open optimal dosing in frail elderly beyond trial subgroups.
Structured PICO
Does dabigatran compared with warfarin have age-dependent effects on stroke and bleeding in patients with atrial fibrillation?
P
Population
18,113 patients with atrial fibrillation from the RE-LY trial, stratified by age categories (<75, 75-79, 80-84, and ≥85 years)
I
Intervention
Dabigatran 150 mg twice daily or 110 mg twice daily
C
Comparator
Warfarin
O
Outcome
Stroke, bleeding (intracranial and extracranial major), and mortalityhard clinical
Dabigatran maintains its stroke prevention benefits across all age groups, but its risk of extracranial major bleeding increases with age, supporting the use of the 110 mg dose in patients aged ≥80 years.
Cite This Study
Lauw et al. (2017) studied this question.