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Case report and literature review reveals occult malignancy presenting as thrombotic microangiopathy, highlighting the need to screen for cancer when conventional therapy fails.
It is currently recognized that the pathogenesis of malignancy-associated thrombotic microangiopathy (TMA) is distinct from thrombotic thrombocytopenic purpura. This carries important implications in its classification and its management. Here, we report a case of occult malignancy presenting initially as acute kidney injury secondary to TMA and highlight the importance of considering an underlying malignancy in patients not responding to conventional therapy for TMA.
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Houston et al. (2011) studied this question.
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