Why the study?
The ACE gene I/D polymorphism has recently been reported to be associated with human cancer pathogenesis, but its potential association with glioblastoma in an Iranian population was unknown.
Is the ACE gene insertion/deletion polymorphism associated with glioblastoma in an Iranian population?
Is the ACE gene insertion/deletion polymorphism associated with glioblastoma in an Iranian population?
The ACE gene DD genotype and D allele are associated with glioblastoma in an Iranian population.
Hypothesis-generating for ACE I/D in glioblastoma risk; larger studies needed before any clinical consideration.
Background . The insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene has recently been reported to be associated with the pathogenesis and development of human cancers. This study aimed to assess the potential association between ACE (I/D) polymorphism and glioblastoma in an Iranian population. Material and Methods . This case-control study was conducted on 80 patients with glioblastoma and 80 healthy blood donors as controls. Gap-polymerase chain reaction (Gap-PCR) was used to determine the ACE (I/D) genotypes. PCR products were separated and measured by electrophoresis on a 2 % agarose gel. Results . Analysis of demographic data showed a significant difference in the family history of cancer between the case and control groups (p=0.03). The distribution of ACE gene variants including II, ID, and DD genotypes was also calculated, and significant differences were seen in the DD genotype (p=0.03) and D allele (p=0.04) between the glioblastoma cases and controls. Conclusion . ACE gene polymorphism was associated with glioblastoma in the study population. Further studies are needed to approve this finding.
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Moqadami et al. (2023) studied this question.
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