Key result
ACE gene II genotype linked to ~80% lower early gastric cancer odds versus DD.
Why the study?
Is the ACE gene insertion/deletion polymorphism associated with the development of early gastric cancer?
Case-Control (n=233)
Is the ACE gene insertion/deletion polymorphism associated with the development of early gastric cancer?
Odds Ratio: 0.2 (95% CI 0.08–0.54)
p-value: p=0.009
The ACE gene insertion/deletion polymorphism, specifically the II genotype, is associated with a reduced risk of early gastric cancer.
Should not yet inform gastric cancer risk assessment; leaves open prospective validation of ACE polymorphism.
The insertion/deletion polymorphism of the angiotensin I-converting enzyme (ACE) gene has recently been linked to the pathogenesis and progression of human cancers. Using genomic DNA from 88 patients with early gastric cancer confined either to mucosa (pT(1a)) or submucosa (pT(1b)), we assessed the insertion (I) and deletion (D) polymorphism by PCR analysis and compared it with a large noncancer control population (n = 145). In the noncancer control group, the II genotype was observed in 33 (23%) individuals, whereas the ID and DD genotypes were found in 72 (50%) and 40 (27%) individuals, respectively. Interestingly, in the cancer group, we found the II genotype in six (7%) patients and the ID genotype in 46 (52%) individuals, whereas the DD genotype was observed in 36 (41%) individuals (P = 0.0034). Accordingly, the odds ratio for the II genotype was 0.20 [95% confidence interval (95% CI), 0.08-0.54; P = 0.009] and 0.55 for the ID/II genotype (95% CI, 0.31-0.96; P = 0.044) using the high-activity genotype DD as the reference category. No correlation was found among tumor type, tumor stage, the presence of Helicobacter pylori, and the ACE genotype. Our study provides further evidence that the ACE insertion/deletion gene polymorphism may be linked to the development of early gastric cancer.
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Ebert et al. (2005) conducted a case-control in Early gastric cancer (n=233). ACE gene II genotype vs. ACE gene DD genotype was evaluated on Early gastric cancer (OR 0.20, 95% CI 0.08-0.54, p=0.009). The ACE gene II genotype was associated with significantly lower odds of early gastric cancer compared to the DD genotype (OR 0.20; 95% CI 0.08-0.54; P=0.009).
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