Key result
The ACE II genotype in gastric cancer patients was significantly associated with fewer lymph node metastases (P<0.001) and a lower UICC tumor stage (P=0.01) compared to the DD genotype.
Why the study?
Does the ACE gene insertion/deletion polymorphism correlate with gastric cancer progression and lymph node metastases?
Case-Control (n=302)
Does the ACE gene insertion/deletion polymorphism correlate with gastric cancer progression and lymph node metastases?
p-value: p=<0.001
The ACE gene insertion/deletion polymorphism correlates with metastatic behavior in gastric cancer, with the II genotype associated with fewer lymph node metastases.
No takes yet. Share an insight, caveat, or question.
ACE I/D polymorphism may influence gastric cancer metastasis; hypothesis-generating and should not yet change practice.
Röcken et al. (2005) conducted a case-control in Gastric cancer (n=302). ACE gene II genotype vs. ACE gene DD genotype was evaluated on Number of lymph node metastases (p=<0.001). The ACE II genotype in gastric cancer patients was significantly associated with fewer lymph node metastases (P<0.001) and a lower UICC tumor stage (P=0.01) compared to the DD genotype.
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