Key result
In intestinal type gastric cancer, AT1R+ tumors with the ACE D allele were associated with a significantly higher risk of lymph node metastases (OR 19.00; 95% CI 1.45-248.24).
Observational (n=100)
Odds Ratio: 19 (95% CI 1.45–248.24)
The combination of AT1R expression and ACE I/D gene polymorphism correlates with nodal spread and shorter survival in intestinal type gastric cancer.
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May inform nodal risk stratification in intestinal gastric cancer; leaves open whether ACE/AT1R targeting reduces metastases.
Röcken et al. (2007) conducted an observational in Gastric cancer (n=100). AT1R expression and ACE D allele vs. AT1R- tumors / other ACE genotypes was evaluated on Lymph node metastases (OR 19.00, 95% CI 1.45-248.24). In intestinal type gastric cancer, AT1R+ tumors with the ACE D allele were associated with a significantly higher risk of lymph node metastases (OR 19.00; 95% CI 1.45-248.24).
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