AT1R and AT2R expression correlates with the malignant potential and histological grade of ovarian epithelial tumors, suggesting a potential role in tumor development and progression.
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AT1R/AT2R expression warrants mechanistic studies in ovarian malignancy; should not yet influence clinical decisions or prognostication.
Background and aims: Recently, activation of the local renin‐angiotensin system via angiotensin II type 1 and 2 receptor (AT1R and AT2R) was shown under neoplastic conditions in certain tumor tissues. We aimed to evaluate the expression of AT1R and AT2R in ovarian epithelial tumors and its correlation with other clinicopathologic parameters including patient survival. Methods: Immunohistochemical staining for AT1R and AT2R were performed by using tissue microarray in 40 benign epithelial tumors (20 serous adenomas and 20 mucinous adenomas), 36 borderline tumors (11 serous tumors and 25 mucinous tumors), and 90 malignant tumors (64 serous carcinomas, 19 mucinous carcinomas, 5 endometrioid carcinomas, and 2 clear cell carcinomas). Additionally, immunostaining for Ki‐67 was performed in 90 malignant epithelial tumors. Results: The expression of AT1R and AT2R were significantly correlated with malignant potential of tumors ( P < 0.001 and P < 0.001, respectively) and histological grade of malignant tumors ( P < 0.001 and P = 0.001, respectively). However, there was no prognostic significance of AT1R and AT2R in ovarian carcinomas. Conclusion: Although the exact roles of angiotensin II receptor in the development of ovarian epithelial tumor is not clear, this study suggests that both AT1R and AT2R may involved in development and progression of ovarian epithelial tumors.
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Hwang et al. (2008) studied this question.
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