April 1, 2005Clinical Cancer Research

Functional Expression of the Angiotensin II Type1 Receptor in Human Ovarian Carcinoma Cells and Its Blockade Therapy Resulting in Suppression of Tumor Invasion, Angiogenesis, and Peritoneal Dissemination

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Why the study?

Does AT1R blockade with candesartan suppress tumor invasion, angiogenesis, and peritoneal dissemination in ovarian carcinoma models?

Population

Human ovarian tumor tissues, AT1R-positive SKOV-3 ovarian cancer cells, and SKOV-3-transplanted athymic mice

Comparison

AT1R blocker (candesartan) vs Untreated control

Design

Preclinical

Authors

TSTakayasu SuganumaNagoya University KIKazuhiko InoWakayama Medical University KSKiyosumi ShibataFujita Health University Hospital

Discussion

Member takes

Implication

Supports AT1R blockade as a potential target in ovarian carcinoma; hypothesis-generating and requires clinical validation.

Structured PICO

Does AT1R blockade with candesartan suppress tumor invasion, angiogenesis, and peritoneal dissemination in ovarian carcinoma models?

Population

Human ovarian tumor tissues (n=99, including 67 invasive adenocarcinomas, 18 borderline malignant tumors, and 14 benign cystadenomas), AT1R-positive SKOV-3 ovarian cancer cells, and SKOV-3-transplanted athymic mice

Intervention

AT1R blocker (candesartan)

Comparator

Untreated control

Outcome

Tumor invasion, VEGF secretion, peritoneal dissemination, and tumor angiogenesissurrogate

AT1R blockade with candesartan suppresses tumor progression and angiogenesis in preclinical models of ovarian carcinoma, suggesting a potential novel therapeutic strategy.

Cite This Study

Suganuma et al. (2005) studied this question.

synapsesocial.com/papers/6a82ad4c0f52607ca18ae106 https://doi.org/10.1158/1078-0432.ccr-04-1946

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Functional Expression of the Angiotensin II Type1 Receptor in Human Ovarian Carcinoma Cells and Its Blockade Therapy Resulting in Suppression of Tumor Invasion, Angiogenesis, and Peritoneal Dissemination

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Functional Expression of the Angiotensin II Type1 Receptor in Human Ovarian Carcinoma Cells and Its Blockade Therapy Resulting in Suppression of Tumor Invasion, Angiogenesis, and Peritoneal Dissemination

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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