May 7, 2009International Journal of OncologyOpen Access

Local angiotensin II-generation in human gastric cancer: Correlation with tumor progression through the activation of ERK1/2, NF-κB and survivin

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Gastric cancer (n=20). Intervention: Gastric cancer tissue vs. Corresponding normal gastric tissue. Primary outcome: Angiotensin II concentration (pg/g wet tissue) (p=<0.05).

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Key result

Angiotensin II concentration was significantly higher in gastric cancer tissues compared to corresponding normal regions (1447 vs 775 pg/g wet tissue), indicating the presence of a local angiotensin II-generating system.

Why the study?

Does the AT1 receptor blocker candesartan improve survival in a mouse model of gastric cancer peritoneal carcinomatosis?

Study Design

Type

Observational (n=20)

Multicenter

Structured PICO

Does the AT1 receptor blocker candesartan improve survival in a mouse model of gastric cancer peritoneal carcinomatosis?

Population

20 patients (mean age 61.5 years, 40% female) with gastric adenocarcinoma who underwent surgical resection without prior chemotherapy or radiation.

Exposure

Candesartan 10 mg/kg/day by gavage (in vivo mouse model); Angiotensin II and Candesartan (in vitro cell lines).

Comparator

Vehicle control (in vivo mouse model); corresponding normal gastric mucosa (human tissue analysis).

Outcome

Survival time in the mouse model of peritoneal carcinomatosis and Angiotensin II concentration in human tumor vs. normal tissues.surrogate

Main Result

Absolute Event Rate: 1447% vs 775%

p-value: p=<0.05

Limitations

Small sample size of human tissue specimens (n=20)
Lack of statistically significant relationship between angiotensin II concentration and clinicopathological findings
Survival and therapeutic efficacy data are limited to a murine model of peritoneal carcinomatosis

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Raises possibility of targeting local RAS in gastric cancer; leaves open whether candesartan improves survival in peritoneal carcinomatosis models.

Cite This Study

Kinoshita (2009) conducted an observational in Gastric cancer (n=20). Gastric cancer tissue vs. Corresponding normal gastric tissue was evaluated on Angiotensin II concentration (pg/g wet tissue) (p=<0.05). Angiotensin II concentration was significantly higher in gastric cancer tissues compared to corresponding normal regions (1447 vs 775 pg/g wet tissue), indicating the presence of a local angiotensin II-generating system.

synapsesocial.com/papers/6a209de448884d7e569117fc https://doi.org/10.3892/ijo_00000287

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Implication

Raises possibility of targeting local RAS in gastric cancer; leaves open whether candesartan improves survival in peritoneal carcinomatosis models.

Local angiotensin II-generation in human gastric cancer: Correlation with tumor progression through the activation of ERK1/2, NF-κB and survivin

Study Design

Structured PICO

Main Result

Limitations

Discussion

Implication

Cite This Study

Local angiotensin II-generation in human gastric cancer: Correlation with tumor progression through the activation of ERK1/2, NF-κB and survivin

Study Design

Structured PICO

Main Result

Limitations

Discussion

Implication

Cite This Study

Also Consider

Also Consider