Key result
ACE and AT2R were significantly upregulated in gastric tumors and metastases, and in vitro inhibition of ACE, AT1R, and AT2R reduced the invasive ability of gastric cancer cell lines.
Population
45 gastric cancer patients and gastric cancer cell lines
Design
Preclinical
Authors
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Local ACE/AT2R upregulation may associate with gastric cancer progression; leaves open whether RAS blockade alters outcomes.
Observational (n=45)
The local angiotensin II system is upregulated in gastric cancer and its activity promotes tumor cell invasion, suggesting a potential pathophysiological role in metastasis.
Carl‐McGrath et al. (2007) conducted an observational in Gastric cancer (n=45). Local angiotensin II system expression (ACE, AT1R, AT2R) vs. Non-lesional tissue was evaluated on Local expression of ACE, AT1R and AT2R and in vitro cell behavior. ACE and AT2R were significantly upregulated in gastric tumors and metastases, and in vitro inhibition of ACE, AT1R, and AT2R reduced the invasive ability of gastric cancer cell lines.
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