Key result
ACE DD genotype linked to ~118% higher odds of advanced prostate cancer.
Why the study?
Genetic factors related to ACE may influence the progression of human prostate cancer, but their association with disease advancement was unclear.
Is the ACE gene DD genotype associated with disease progression in patients with prostate cancer?
Observational (n=170)
Is the ACE gene DD genotype associated with disease progression in patients with prostate cancer?
Odds Ratio: 2.18 (95% CI 1.11–4.03)
Absolute Event Rate: 39.8% vs 23.2%
p-value: p=0.024
The ACE gene DD genotype is significantly associated with advanced disease in patients with prostate cancer, suggesting genetic factors related to ACE may influence tumor behavior.
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ACE DD genotype was associated with advanced prostate cancer; hypothesis-generating for genetic risk stratification and does not yet alter management.
Medeiros et al. (2004) conducted an observational in Prostate cancer (n=170). ACE DD genotype vs. Non-DD genotypes was evaluated on Advanced disease (OR 2.18, 95% CI 1.11-4.03, p=0.024). The ACE DD genotype was significantly more frequent in patients with advanced prostate cancer compared to those with localized disease (39.8% vs 23.2%; OR 2.18, 95% CI 1.11-4.03; p=0.024).
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