Key points are not available for this paper at this time.
Answers are grounded in this paper and cite their sources.
Cilnidipine may attenuate sympathetic overactivity versus amlodipine in CKD hypertension; leaves open whether outcomes improve.
Hypertension with chronic kidney disease is a widely prevalent public health concern. Calcium channel blockers are a commonly used class of drugs for the treatment of hypertension. L-type calcium channel blockers like amlodipine cause a reflex sympathetic overactivity, which predisposes to increased cardiovascular morbidity and mortality. Also, the effect of L-type CCBs on urinary protein excretion is uncertain. Cilnidipine is a novel CCB with a dual L/N-type calcium channel blocking property, thus favouring additional renal and cardiovascular protection.
No takes yet. Share an insight, caveat, or question.
Gowda et al. (2017) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: