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June 1, 2002Journal of Biological ChemistryOpen Access

A Novel Peroxide-induced Calcium Transient Regulates Interleukin-6 Expression in Cardiac-derived Fibroblasts

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Population

Cardiac derived fibroblasts isolated from adult male rats

Comparison

Single 3-min pulse of 100 microm H(2)O(2) vs Absence of extracellular calcium, pretreatment…

Design

Preclinical

Follow-up

24 hours

Authors

JCJames T. ColstonBCBysani ChandrasekarGFGregory L. Freeman

Discussion

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Overview

Suggests oxidative stress–IL-6 link in cardiac fibroblasts; leaves open in vivo role in post-ischemic inflammation.

Structured PICO

P
Population
Cardiac derived fibroblasts isolated from adult male rats
I
Intervention
Single 3-min pulse of 100 microm H(2)O(2)
C
Comparator
Absence of extracellular calcium, pretreatment with xestospongin C, or pretreatment with thapsigargin
O
Outcome
Intracellular Ca(2+) transient magnitude and IL-6 expression (mRNA and protein release)surrogate

Brief exposure of cardiac fibroblasts to H(2)O(2) induces a large calcium transient and calcium-dependent IL-6 expression, highlighting a potential mechanism for post-ischemic inflammation.

Cite This Study

Colston et al. (2002) studied this question.

synapsesocial.com/papers/6a7194cd6ceb2bbd16e02fcahttps://doi.org/10.1074/jbc.m108676200
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