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August 4, 2026Trends in ParasitologyOpen Access

Sensing the enemy within: Vγ9Vδ2 T cells as metabolic sensors of intracellular parasites

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Authors

FRFelipe RodriguezUniversity of California, DavisJSJeroen P. J. SaeijUniversity of California, Davis

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Implication

Review synthesizes the role of Vγ9Vδ2 T cells in detecting intracellular parasites, suggesting new therapeutic approaches.

Key Points

  • This review aims to consolidate current knowledge on Vγ9Vδ2 T cells and their responses to intracellular parasites.
  • Examined the immunobiology of Vγ9Vδ2 T cells and their recognition of nonpeptidic phosphoantigens.
  • Discussed the heteromeric interaction between BTN3A1 and BTN2A1 receptors.
  • Reviewed the cytotoxic responses and interferon gamma production triggered by parasite detection.
  • Vγ9Vδ2 T cells utilize intracellular phosphoantigens to initiate rapid cytotoxic activity against Plasmodium falciparum and Toxoplasma gondii.
  • The study highlights the receptors involved in activating γδ T cells, enhancing their immune response.
  • This understanding provides a foundation for exploring new antiparasitic therapies and vaccine strategies.

Cite This Study

Rodriguez et al. (2026) studied this question.

synapsesocial.com/papers/6a7198eec47350ef8e494552https://doi.org/10.1016/j.pt.2026.07.007
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