Why the study?
Does a multimarker panel including MCP, MPO, CRP, and BNP accurately rule out acute coronary syndromes in low-risk emergency department patients?
Population
414 low-risk emergency department patients evaluated for acute coronary syndrome in a chest pain unit
Design
Cohort, Outcomes adjudicated by three blinded reviewers
Follow-up
45 days
Authors
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Does not support multimarker panel for ACS rule-out in low-risk ED patients; leaves open validation of superior strategies.
Does a multimarker panel including MCP, MPO, CRP, and BNP accurately rule out acute coronary syndromes in low-risk emergency department patients?
A multimarker panel including MCP, MPO, CRP, and BNP had unexpectedly low sensitivity and specificity for ruling out ACS in low-risk ED patients, making it an inefficient screening tool.
Mitchell et al. (2006) studied this question.
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