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August 4, 2026Korean Journal of MedicineOpen Access

A 62-Year-Old Man with Weakness and Weight Loss for 3 Months

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Authors

SSSook Hyun ShinSoonchunhyang UniversityJYJeong‐Ju YooSoonchunhyang UniversitySKSang Gyune KimHallym University

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Overview

Randomized trial investigates surveillance strategies for hepatocellular carcinoma in non-cirrhotic MASLD, suggesting potential improvements in risk detection.

Key Points

  • This research aims to identify effective surveillance strategies for hepatocellular carcinoma arising from non-cirrhotic metabolic dysfunction-associated steatotic liver disease.
  • Reviewed current literature on MASLD and HCC.
  • Evaluated biomarkers and non-invasive tests for early detection.
  • Discussed potential of liquid biopsy for risk stratification.
  • A significant proportion of HCC cases arise in non-cirrhotic MASLD patients.
  • Current surveillance strategies remain unclear, indicating a gap in the management of these patients.
  • Emerging biomarkers and non-invasive techniques show promise for improving early detection.

Cite This Study

Shin et al. (2026) studied this question.

synapsesocial.com/papers/6a719922c47350ef8e4948cehttps://doi.org/10.3904/kjm.2026.101.4.189
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Risk Assessment and Prediction of Hepatocellular Carcinoma in Noncirrhotic Metabolic Dysfunction-Associated Steatotic Liver Disease2026
  2. 2From mechanisms to management: Early detection and improved treatment of MASLD and its related hepatocellular carcinoma2025 · 4 citations
  3. 3Hepatocellular Carcinoma in Metabolic Dysfunction-Associated Steatotic Liver Disease Beyond Fibrosis: Metabolic, Microbial, and Immune Determinants2026
  4. 4Cardiometabolic risk factors in MASLD patients with HCC: the other side of the coin2024 · 10 citations
  5. 5MASLD-related HCC: Multicenter study comparing patients with and without cirrhosis2024 · 13 citations