What question did this study set out to answer?

To review the mechanisms of microglial activation in ischemic brain injury and examine how molecular signaling pathways influence microglial phenotypes and stroke pathology.

November 12, 2009Future NeurologyOpen Access

Microglia in ischemic brain injury

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To review the mechanisms of microglial activation in ischemic brain injury and examine how molecular signaling pathways influence microglial phenotypes and stroke pathology.
Reviewed experimental literature covering in vitro and in vivo ischemic conditions alongside human clinical histological and radiological neuroimaging data.
Evaluated direct effects of in vitro ischemic conditions on microglial genomic profiles and phenotypes, focusing on hypoxia-inducible factor-1 and Toll-like receptor-4 signaling.
Ischemia rapidly shifts surveying microglia into alerted or reactive phenotypes, accompanied by leukocyte infiltration and extensive neuroinflammatory gene expression changes.
Signaling mediated by hypoxia-inducible factor-1 and Toll-like receptor-4 regulates microglial ischemic responses, while ischemic preconditioning offers a viable approach to suppress harmful microglial activation.

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Implication

Narrative review reveals microglial phenotypic and signaling shifts in stroke patients and models, highlighting therapeutic targets to reduce brain injury.

Cite This Study

Weinstein et al. (2009) studied this question.

synapsesocial.com/papers/6a7199bbe36a167817e360cf https://doi.org/10.2217/fnl.10.1

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Implication

Narrative review reveals microglial phenotypic and signaling shifts in stroke patients and models, highlighting therapeutic targets to reduce brain injury.

Microglia in ischemic brain injury

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Discussion

Implication

Cite This Study

Microglia in ischemic brain injury

Key Points

Discussion

Implication

Cite This Study

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