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March 12, 2004Proceedings of the National Academy of SciencesOpen Access

Transplantation of skeletal myoblasts secreting an IL-1 inhibitor modulates adverse remodeling in infarcted murine myocardium

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Why the study?

Does implantation of skeletal myoblasts expressing sIL-1ra improve cardiac function and attenuate adverse remodeling in a murine model of myocardial infarction?

Population

Female nude mice with myocardial infarction induced by left coronary artery occlusion

Comparison

Implantation of stable murine male skeletal… vs Implantation of nonexpressing SkM lines, or…

Design

Preclinical

Follow-up

3 weeks

Authors

BMBari MurtuzaChildren's Hospital of PittsburghKSKen SuzukiThe University of TokyoGBGeorge Bou–GhariosUniversity of Liverpool

Discussion

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Implication

Hypothesis-generating for IL-1ra myoblast delivery post-MI; extends preclinical remodeling data but leaves open clinical translation.

Structured PICO

Does implantation of skeletal myoblasts expressing sIL-1ra improve cardiac function and attenuate adverse remodeling in a murine model of myocardial infarction?

P
Population
Female nude mice with myocardial infarction induced by left coronary artery occlusion
I
Intervention
Implantation of stable murine male skeletal myoblast (SkM) lines (5 x 10^5 cells) expressing secretory IL-1 receptor antagonist (sIL-1ra) into infarct border zones immediately after occlusion
C
Comparator
Implantation of nonexpressing (cont) SkM lines, or MI-only
O
Outcome
LV ejection fraction (LVEF), end-diastolic diameter, and transmitral peak early/late (E/A) flow velocity ratio at 3 weekssurrogate

Implantation of skeletal myoblasts expressing an IL-1 inhibitor improves cardiac function and attenuates adverse remodeling post-MI in mice, associated with improved graft survival.

Cite This Study

Murtuza et al. (2004) studied this question.

synapsesocial.com/papers/6a719b90febe604dd70a31b6https://doi.org/10.1073/pnas.0306205101
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