Why the study?
Does IL-1ra gene transfection reduce infarct size and apoptosis in a rat model of myocardial ischemia-reperfusion injury?
Population
Rat hearts heterotopically transplanted, subjected to 30 minutes of ischemia by left coronary artery…
Comparison
Transfection with human secreted-type IL-1ra… vs Control-transfected hearts
Design
Preclinical
Follow-up
24 hours
Authors
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IL-1ra transfection merits further preclinical testing; leaves open translation to human ischemia-reperfusion injury.
Does IL-1ra gene transfection reduce infarct size and apoptosis in a rat model of myocardial ischemia-reperfusion injury?
IL-1ra gene transfection protects the myocardium from ischemia-reperfusion injury by attenuating inflammation and apoptosis in a rat model.
Murtuza et al. (2001) studied this question.
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