Key result
IL-1ra gene transfection reduces infarct size ~42% vs control after ischemia-reperfusion injury.
Why the study?
IL-1 mediates acute inflammation during myocardial ischemia-reperfusion injury leading to necrosis and apoptosis, and IL-1ra may protect myocardium by inhibiting these effects.
Does IL-1ra gene transfection reduce infarct size and apoptosis in a rat model of myocardial ischemia-reperfusion injury?
Population
Rat hearts heterotopically transplanted subjected to 30 minutes ischemia and 24 hours reperfusion
Comparison
IL-1ra gene transfection vs control transfection
Design
Preclinical gene transfection study with intracoronary infusion and heterotopic transplantation
Follow-up
24 hours
Authors
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IL-1ra overexpression may limit I/R injury; leaves open clinical translation in myocardial infarction.
Does IL-1ra gene transfection reduce infarct size and apoptosis in a rat model of myocardial ischemia-reperfusion injury?
Absolute Event Rate: 26.9% vs 46.2%
p-value: p=0.001
Overexpression of IL-1ra via gene transfection significantly reduces infarct size and apoptosis following ischemia-reperfusion injury in a rat model.
Suzuki et al. (2001) studied Ischemia-reperfusion injury. IL-1ra gene transfection vs. Control-transfected hearts was evaluated on Infarct size (p=0.001). IL-1ra gene transfection significantly decreased infarct size compared with control-transfected hearts (26.9% vs 46.2%, P=0.001) following ischemia-reperfusion injury.
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